AustralieFrV1, Main, Exploration, bibRecord, 000E81

DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression.

Identifieur interne : 000E81 ( Main/Exploration ); précédent : 000E80; suivant : 000E82

DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression.

Auteurs : Dilys Lam [Australie] ; Marie-Laure Ancelin [France] ; Karen Ritchie [Royaume-Uni] ; Richard Saffery [Australie] ; Joanne Ryan [Australie]

Source :

Psychoneuroendocrinology [ 1873-3360 ] ; 2017.

RBID : pubmed:29132028

Abstract

Depression is one of the most prevalent psychiatric disorders, and in older persons is associated with high levels of comorbidity and under-treatment. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) stress axis is consistently observed in the older population as well as depressed patients, with the angiotensin converting enzyme (ACE) a key regulator of the stress response. Epigenetic regulation of ACE may play an important role in HPA axis (dys)regulation.

DOI: 10.1016/j.psyneuen.2017.11.003
PubMed: 29132028

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Depression is one of the most prevalent psychiatric disorders, and in older persons is associated with high levels of comorbidity and under-treatment. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) stress axis is consistently observed in the older population as well as depressed patients, with the angiotensin converting enzyme (ACE) a key regulator of the stress response. Epigenetic regulation of ACE may play an important role in HPA axis (dys)regulation.</div>
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Serveur d'exploration sur les relations entre la France et l'Australie

DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression.

DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression.

Source :

Abstract

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